NMR in Glycoscience and Glycotechnology
Contributions by Daron I Freedberg, Anthony S Serianni, Mario Schubert, James Prestegard, J Jimenez-Barbero, Koichi Kato, Thomas Peters, Yoshiki Yamaguchi, Adam Barb, Vitor H Pomin, Xu Wang, Yu Nakagawa, Mei Hong, Marco Guerrini, Goran Widmalm, William York, Jun Kikuchi Edited by Koichi Kato, Thomas Peters Series edited by Masatsune Kainosho Editor-in-chief William Price
Publication date:15 May 2017
Length of book:402 pages
PublisherRoyal Society of Chemistry
This volume focuses on solution and solid-state NMR of carbohydrates, glycoproteins, glyco-technologies, biomass and related topics. It is estimated that at least 80% of all proteins are glycoproteins. Because of the complexity, heterogeneity and flexibility of the sugar chains, the structural biology approaches for glycoconjugates have been generally avoided. NMR techniques although well established for structural analyses of proteins and nucleic acids, cannot be simply applied to this complex class of biomolecules. Nonetheless, recently developed NMR techniques for carbohydrates open the door to conformational studies of a variety of sugar chains of biological interest. NMR studies on glycans will have significant impact on the development of vaccines, adjuvants, therapeutics, biomarkers and on biomass regeneration.
In this volume, the Editors have collected the most up-to-date NMR applications from experts in the field of carbohydrate NMR spectroscopy. Timely and useful, not only for NMR specialists, it will appeal to researchers in the general field of structural biology, biochemistry and biophysics, molecular and cellular biology and material science.